The name Oprah means Gazelle and is of Hebrew origin. Oprah is a name that's been used primarily by parents who are considering baby names for girls.
Oprah is a created name, made famous by Oprah Winfrey, talk show host. Winfrey says that her name was originally Orpah on her birth certificate, but was constantly being mispronounced by her family. They legally changed her name to Oprah at the age of 1.