The meaning of the name Khaleesi is Created Name. The origin of the name Khaleesi is American. This is the culture in which the name originated, or in the case of a word, the language.
In George R.R. Martin's Song of Ice and Fire novels and Game of Thrones TV series, the title "Khaleesi" refers to the wife of the Khal, a warlord of the Dothraki tribe.