What does the name Serena mean? The meaning of the name Serena is Serene, Calm. The origin of the name Serena is Latin. This is the culture in which the name originated, or in the case of a word, the language.
Alternate spellings: Sarena, Serina, Cerina
People who like the name Serena also like: Aria
, Ava Liam
Name Notes: Serena Williams, tennis pro.