What does the name Lupe mean? The meaning of the name Lupe is From The River Of The Wolf. The origin of the name Lupe is Spanish. This is the culture in which the name originated, or in the case of a word, the language.
People who like the name Lupe also like: Amelia
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Name Notes: Short form of the name Guadelupe.
Tía Lupe - Alien Ant Farm