What does the name Guadalupe mean? The meaning of the name Guadalupe is River Of The Wolf. The origin of the name Guadalupe is Spanish. This is the culture in which the name originated, or in the case of a word, the language.
Alternate spellings: Guadelupe
People who like the name Guadalupe also like: Raul
, Sebastien Esperanza
Name Notes: Name given to honor the Virgin Mary, in Hispanic cultures titled "Our Lady of Guadalupe."